tert-butyl 3-carbamoylpiperidine-1-carboxylate - Names and Identifiers
Name | 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester
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Synonyms | N-Boc-Nipecotamide 1-Boc-3-piperidinecarboxamide 1-N-BOC-3-CARBAMOYLPIPERIDINE 1-Boc-piperidine-3-carboxamide 1-N-Boc-3-piperidinecarboxamide 1-N-BOC-PIPERIDINE-3-CARBOXAMIDE 1-TERT-BUTOXYCARBONYL-3-METHYLAMINOPIPERIDINE tert-butyl 3-carbamoylpiperidine-1-carboxylate tert-butyl 3-(aminocarbonyl)piperidine-1-carboxylate 3-CARBAMOYL-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester
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CAS | 91419-49-7
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InChI | InChI=1/C11H20N2O3/c1-11(2,3)16-10(15)13-6-4-5-8(7-13)9(12)14/h8H,4-7H2,1-3H3,(H2,12,14) |
tert-butyl 3-carbamoylpiperidine-1-carboxylate - Physico-chemical Properties
Molecular Formula | C11H20N2O3
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Molar Mass | 228.29 |
Density | 1.123±0.06 g/cm3(Predicted) |
Melting Point | 174.0 to 178.0 °C |
Boling Point | 384.4±31.0 °C(Predicted) |
Flash Point | 186.3°C |
Vapor Presure | 4.1E-06mmHg at 25°C |
pKa | 16.41±0.20(Predicted) |
Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
Refractive Index | 1.498 |
MDL | MFCD06658365 |
tert-butyl 3-carbamoylpiperidine-1-carboxylate - Risk and Safety
Risk Codes | 22 - Harmful if swallowed
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Safety Description | 37 - Wear suitable gloves.
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HS Code | 29333990 |
tert-butyl 3-carbamoylpiperidine-1-carboxylate - Introduction
1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester, chemical name is 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester.
Nature:
-Appearance: Colorless or light yellow liquid.
-Molecular formula: C12H21N3O3.
-Molecular weight: 255.32g/mol.
-Melting point:-28°C.
-Boiling point: 280°C.
-Solubility: Soluble in anhydrous organic solvents, such as ethanol, mini.
Use:
- 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester is an important organic synthesis intermediate, commonly used in drug synthesis.
-It can be used to prepare various piperidine compounds, such as antidepressants, antipsychotic drugs and analgesic drugs.
Method:
The preparation method of 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyyl ester is generally carried out by the following steps:
-First, piperidinecarboxamide is reacted with dimethyl sulfoxide (DMSO) to generate N,N-dimethylthiopiperidecarboxamide.
-Then, in the presence of tert-butylcarbonyl chloride (TBTC), N,N-dimethylthiopiperidinecarboxylic amide was converted into 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylthylethyl ester by acyloxidation.
Safety Information:
- 1-Piperidinecarboxylic acid, 3-(aminocarbonyl)-, 1,1-dimethylethyl ester is an organic compound, which may have certain risks to human health.
-In use, appropriate personal protective measures are required, such as wearing protective glasses, gloves and protective clothing.
-Avoid contact with skin, eyes and mucous membranes.
-Avoid inhaling vapors or dust.
-Keep sealed when stored, away from fire and oxidant.
-Correct laboratory safety procedures should be followed when handling this compound. It is best to operate under the guidance of an experienced chemical professional.
Last Update:2024-04-09 21:32:44